Highlights
- •Patients should be monitored in terms of development of cognitive impairment.
- •Cognitive assessment should be performed for early diagnosis.
- •Patients of advanced age, living alone, with low education, and with high disability score should be monitored more closely.
- •Turkey, a country between Europe and Asia has characteristics of both continents including cognitive impairment in MS.
Abstract
Background
Cognitive impairment (CI) is a common problem in multiple sclerosis (MS), may occur
either in early or late phase of the disease, and impairs quality of life.
Objectives
This study aimed to determine the prevalence of CI and related risk factors in relapsing-remitting
MS (RRMS) patients in Turkey.
Methods
The present cross-sectional, multi-center, and nationally representative study included
RRMS patients. Sociodemographic characteristics, cognitive functions and additional
outcomes were compared between patients with and without CI.
Results
The analyses included 487 RRMS patients. According to the BRB-N battery results, CI
prevalence was 53.7%. There was a negative significant correlation of BRB-N subtests
with age, disease duration, and EDSS and MSNQ-patient rated scores. On the logistic
regression analysis, increased age, living in village/rural area, high income level,
and high EDSS score were significant increasing risk factors in the development of
CI.
Conclusions
This is the first national cognitive data obtained from MS in Turkey, which is a country
between Europe and Asia and thus has characteristics of both continents. The similarity
of the results of the present study obtained from Turkey to the Western-based data
indicates that CI is universal in MS and the main factors affecting CI have not changed.
Keywords
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References
- Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study.PLoS One. 2013; 8: e71058
- Risk factors for and management of cognitive dysfunction in multiple sclerosis.Nat. Rev. Neurol. 2011; 7: 332-342
- Pain and cognition in multiple sclerosis.Curr. Top. Behav. Neurosci. 2014; 20: 201-215
- The brief repeatable battery of neuropsychological tests: normative values allow application in multiple sclerosis clinical practice.Mult. Scler. 2001; 7: 263-267
- Fatigue is associated with poor sleep in people with multiple sclerosis and cognitive impairment.Mult. Scler. Int. 2014; 2014: 872732
- Cognitive impairment in multiple sclerosis.Lancet Neurol. 2008; 7: 1139-1151
- A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: changes in health-related quality of life and the value of different factors in predicting health-related quality of life.J. Neurol. Sci. 2014; 339: 57-63
- Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis.J. Neurol. Neurosurg. Psychiatry. 2005; 76: 519-526
- How to detect cognitive dysfunction at early stages of multiple sclerosis?.Mult. Scler. 2006; 12: 445-452
- Patient characteristics and determinants of quality of life in an international population with multiple sclerosis: assessment using the MusiQoL and SF-36 questionnaires.Mult. Scler. 2011; 17: 1238-1249
- Cognitive dysfunction in multiple sclerosis.Front. Neurol. 2012; 3: 74
- Depression and cognitive impairment in disability-free early multiple sclerosis.Behav. Neurol. 2003; 14: 39-45
- The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis.Mult. Scler. 2007; 13: 81-86
- Cognitive functioning in multiple sclerosis.Neurol. Clin. 2011; 29: 507-525
- The relationship of cognitive impairment with neurological and psychiatric variables in multiple sclerosis patients.Int. J. Psychiatry Clin. Pract. 2014; 18: 45-51
- [The influence of age and illness duration on cognitive impairment in aging patients with relapsing-remitting multiple sclerosis (RR-MS)].Geriatr. Psychol. Neuropsychiatr. Vieil. 2014; 12: 331-338
- Cognitive impairment in multiple sclerosis.Curr. Neurol. Neurosci. Rep. 2012; 12: 618-627
- Cognitive dysfunction in multiple sclerosis: the effect of pharmacological interventions.Int. Rev. Psychiatry. 2010; 22: 35-42
- Assessment and rehabilitation of cognitive impairment in multiple sclerosis.Int Rev. Psychiatry. 2010; 22: 22-34
- Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis.Mult. Scler. 2006; 12: 77-87
- Cognitive dysfunction in multiple sclerosis: methods and prevalence from the GEDMA Study.Eur. Neurol. 2009; 61: 87-93
- Utilization of the multiple sclerosis functional composite in follow-up: relationship to disease phenotype, disability and treatment strategies.J. Neurol. Sci. 2005; 232: 65-69
- Cognitive impairment in multiple sclerosis.Mult. Scler. 2009; 15: 2-8
- Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.Mult. Scler. 2009; 15: 779-788
- Prevalence and incidence of cognitive impairment in multiple sclerosis: a population-based survey in Catania, Sicily.J. Neurol. 2015; 262: 923-930
- A short version of Rao's Brief Repeatable Battery as a screening tool for cognitive impairment in multiple sclerosis.Clin. Neuropsychol. 2009; 23: 268-275
- Cognitive impairment in different MS subtypes and clinically isolated syndromes.J. Neurol. Sci. 2008; 267: 100-106
- Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis.J. Neurol. Neurosurg. Psychiatry. 2011; 82: 1157-1159
- Cognitive impairment, health-related quality of life and vocational status at early stages of multiple sclerosis: a 7-year longitudinal study.J. Neurol. 2013; 260: 776-784
- Cognitive impairment in patients suffering from relapsing-remitting multiple sclerosis with EDSS < or = 3.5.Acta Neurol. Scand. 2003; 108: 323-326
- The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis.J. Neurol. 2008; 255: 910-916
- Cognitive impairment after three decades of multiple sclerosis.Eur. J. Neurol. 2010; 17: 499-505
- Multiple sclerosis with predominant, severe cognitive impairment.Arch. Neurol. 2009; 66: 1139-1143
- Cognitive impairment in multiple sclerosis.Folia Med. 2016; 58: 157-163
- Cognitive dysfunction in multiple sclerosis: assessment, imaging, and risk factors.J. Rehabil. Res. Dev. 2006; 43: 63-72
Article info
Publication history
Published online: March 26, 2018
Accepted:
March 13,
2018
Received:
March 1,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
