Highlights
- •Muscle carnosine is related to contractile function and buffering of exercise–induced acidosis.
- •Muscle carnosine is substantially reduced in an animal MS model (EAE) and MS.
- •Exercise therapy does not restore reduced muscle carnosine in EAE.
Abstract
Background
Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise–induced acidosis. As these muscular functions
are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine
levels in MS.
Methods
Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental
autoimmune encephalomyelitis, n = 40) and controls (CON, n = 40) before and after
exercise training (EAEEX, CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAESED, CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients
(n = 24) was measured.
Results
EAE muscle carnosine levels were decreased (p < .0001) by ~ 40% to ~ 64% at 10d and
17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly,
human MS muscle carnosine levels were decreased (− 25%, p = .03).
Conclusion
Muscle carnosine concentrations in an animal MS model and MS patients are substantially
reduced. In EAE exercise therapy does not restore this.
Keywords
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Article info
Publication history
Published online: February 11, 2018
Accepted:
February 9,
2018
Received in revised form:
January 31,
2018
Received:
November 22,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
