Highlights
- •Biogenic amines are direct mediators of interactions between immune and nervous systems in multiple sclerosis.
- •Biogenic amines have an immunomodulatory effect on Th17-cells.
- •Targeting of biogenic amines could be explored as a new kind of additional disease-modifying treatment of multiple sclerosis.
Abstract
Biogenic amines are direct mediators of interactions between immune and nervous systems
implicated in the pathogenesis of multiple sclerosis (MS). Recently, great attention
has been drawn to studying the effects of biogenic amines on Th17-cells, which play
one of the central roles in the development of inflammatory lesions in MS. Results
of these studies suggest that, depending on the activation of particular receptors,
biogenic amines can both enhance and inhibit Th17-cell functions. Based on these data,
targeting biogenic amines and their receptors could be explored as a new kind of additional
disease-modifying treatment of MS.
Keywords
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Article info
Publication history
Published online: February 12, 2018
Accepted:
February 9,
2018
Received in revised form:
February 5,
2018
Received:
July 31,
2017
Identification
Copyright
© 2018 Published by Elsevier B.V.
