Highlights
- •MOG-IgG disorders are a clinical spectrum that could involve brainstem.
- •Rhombencephalitis (with transverse myelitis) could be caused by MOG-IgG.
- •Patients with MOG-IgG disorder could recover massively from severe attacks.
Abstract
Introduction
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) associated disorders present
with a spectrum of clinical pictures including brainstem involvement.
Case report
A patient with the sudden onset of a post-partum severe rhombencephalitis causing
respiratory failure (12 years after a mild transverse myelitis). Despite the aggressive
clinical course, she had an impressive recovery after plasmapheresis, and no further
relapses on immunosuppression.
Conclusion
MOG-IgG disorders could relapse several years after onset and involve brainstem. Good
prognosis is possible after treatment.
Abbreviation:
MOG-IgG (myelin oligodendrocyte glycoprotein antibodies), NMOSD (neuromyelitis optica spectrum disorders), AQP4 (aquaporin-4), LETM (longitudinal extensive transverse myelitis), MRI (magnetic resonance imaging), CE (gadolinium enhancement), CSF (cerebrospinal fluid), ADEM (acute demyelinating encephalomyelitis), FLAIR (Fluid Attenuated Inversion Recovery)Keywords
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References
- MOG-IgG in NMO and related disorders: a multicenter study of 50 patients.J. Neuroinflamm. 2016; 1: 13-281
- Clinical presentation and prognosis in MOG-antibody disease: a UK study.Brain. 2017; 1: 3128-3138
- Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients.Mult. Scler. 2014; 20: 843-847
- The spectrum of MOG autoantibody-associated demyelinating diseases.Nat. Rev. Neurol. 2013; 9: 455-461
- Ann. Clin. Transl. Neurol. 2015; 2: 295-301
Article info
Publication history
Published online: February 08, 2018
Accepted:
February 5,
2018
Received in revised form:
January 30,
2018
Received:
December 5,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
