Highlights
- •CI patients had more disability and psychological distress than non-CI MS patients.
- •Third ventricle width, corpus callosum index and lesion volume predicted CI in MS.
- •None of the 3D MRI subcortical structures predicted cognitive function in MS.
Abstract
Background
Cognitive impairment (CI) has been associated with numerous magnetic resonance imaging
(MRI) indices in multiple sclerosis (MS) patients. In this study we investigated the
association of a large set of 2D and 3D MRI markers with cognitive function in MS.
Methods
A sample of 61 RRMS patients (mean age 41.8 ± 10.6 years old, 44 women, mean disease
duration 137.9 ± 83.9 months) along with 51 age and gender matched healthy controls
was used in this cross-sectional study. Neuropsychological and other tests, along
with a large set of 2D/3D MRI evaluations were made.
Results
44.3% of patients had CI. CI patients had more disability, physical fatigue than non-CI
patients and more psychological distress than non-CI patients and HCs. Also, CI patients
had significantly larger third ventricle width and volume, smaller coprus callosum
index and larger lesion volume than non-CI patients. These MRI markers also significantly
predicted cognitive scores after adjusting for age and education, explaining about
30.6% of the variance of the total cognitive score.
Conclusions
Selected linear and volumetric MRI indices predict cognitive function in MS. Future
studies should expand these results by exploring longitudinal changes and producing
normative data.
Keywords
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Article info
Publication history
Published online: February 06, 2018
Accepted:
February 3,
2018
Received:
December 19,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
