Highlights
- •Oligoclonal bands of IgG (OB) are proposed as an early prognostic factor of the disease.
- •Growing attention is directed towards brain volume as a possible marker of the severity of MS.
- •In our study OB positive patients show more white matter atrophy since early phases.
- •Our data supporting the role of CSF analysis as a prognostic factor in MS.
Abstract
Background
Oligoclonal bands of IgG (OB) are proposed as an early prognostic factor of the disease.
Growing attention is directed towards brain volume evaluation as a possible marker
of the severity of MS. Previous studies found that MS patients lacking OB have less
brain atrophy.
Aim
to evaluate a possible relationship between OB and cerebral volume in a cohort of
early MS patients.
Methods
Inclusion criteria were: diagnosis of relapsing-remitting MS; CSF analysis and MRI
acquired simultaneously and within 12 months from clinical onset. A total of 15 healthy
controls underwent MRI.
Results
In 20 MS patients, CSF analysis did not show OB synthesis (OB negative group). A control
group of 25 MS patients in whom OB was detected was also randomly recruited (OB positive
group). T test showed a significant difference in NWV between the OB positive and
OB negative groups (P value = 0.01), and between the OB positive group and the healthy
controls (P value = 0.001). No differences were detected between OB negative group
and healthy controls.
Multivariable linear regression showed a relationship between NWV and OB synthesis
(P value = 0.02) controlling for age, gender, and EDSS.
Conclusions
Our preliminary results suggest that OB positive patients show more atrophy of white
matter since early phases of the disease, supporting the role of CSF analysis as a
prognostic factor in MS.
Keywords
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Article info
Publication history
Published online: November 07, 2017
Accepted:
November 5,
2017
Received in revised form:
November 3,
2017
Received:
August 20,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
