Highlights
- •The Expanded Disability Status Scale (EDSS) is dominated by ambulation.
- •Functional composite endpoints improve the sensitivity of measuring disability in MS.
- •The MS Functional Composite (MSFC) is a proven measure of disability in MS.
- •Including the Symbol Digit Modality test improves the utility of the MSFC.
- •Adding MS-specific measures of quality of life to the MSFC improves the test further.
Abstract
Abbreviations:
BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis), BVMT-R (Brief Visuospatial Memory Test-Revised), CVLT-II (California Verbal Learning Test-Second Edition), DAF (disease activity-free status), EDSS (Expanded Disability Status Scale), MACFIMS (Minimal Assessment of Cognitive Function in MS), MSFC (MS Functional Composite), MusiQoL (MS International Quality of Life), PASAT (Paced Auditory serial Addition test), QoL (quality of life), SDMT (Symbol Digit Modalities Test)Keywords
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