This our largest issue of MSARD, thanks to the outstanding and growing number of high quality submissions to this new journal. We have 4 reviews starting with a provocative analysis of the state of MS genetics by Co-Chief Editor, Chris Hawkes. It is our hope that his pointed opinions will generate lively discourse on the topic. This journal and others have had many papers on the relative roles of genetics, epigenetics and environmental factors in susceptibility to MS and we expect that there will be many more as these areas are developed and continue to converge. There is a review of CNS vasculitis in children by Twilt and Benseler. Galetta and Balcer review the insights coming from new tools for analyzing visual pathways in patients with MS. The last review by Kowalec and colleagues discusses the potential use of pharmacogenomics to assist identification of adverse drug reactions and interactions.
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