Histopathology has demonstrated extensive cortical grey matter (GM) demyelination in multiple sclerosis (MS), and suggests that sulcal folds may be preferentially affected, particularly in progressive MS. This has not been confirmed in vivo, and it is not known if it is relevant to clinical status.
To determine sulcal and gyral crown magnetisation transfer ratio (MTR) in MS cortical GM, and the MTR associations with clinical status.
We measured sulcal and gyral crown cortical GM MTR values in 61 MS patients and 32 healthy controls. Disability was measured using Expanded Disability Status Scale and Multiple Sclerosis Functional Composite scores.
MTR values were reduced in sulcal and gyral crown regions in all MS subtypes, more so in secondary progressive (SP) MS than relapsing remitting (RR) MS, and similarly in primary progressive (PP) MS and RRMS. Sulcal MTR was lower than gyral crown MTR in controls, PPMS and RRMS patients, but not in SPMS. MTR correlated with clinical status in RRMS and SPMS, but not PPMS.
Cortical pathology, as reflected by MTR, is present in all MS subtypes and most pronounced in SPMS. A preferential disease effect on sulcal cortical regions was not observed. Cortical MTR abnormalities appear to be more clinically relevant in relapse-onset rather than progressive-onset MS.
- MTR abnormalities are present in all MS subtypes and are most pronounced in SPMS.
- Sulcal MTR was lower than gyral MTR in controls, PPMS and RRMS, but not SPMS.
- MTR correlated with clinical status in RRMS and SPMS, but not PPMS.
- Cortical MTR may be more clinically relevant in relapse- than progressive-onset MS.
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Published online: February 15, 2013
Accepted: January 10, 2013
Received in revised form: December 19, 2012
Received: September 27, 2012
© 2013 Elsevier B.V. Published by Elsevier Inc. All rights reserved.