Highlights
- •This study focuses on the evaluation of metabolic syndrome parameters.
- •The study includes adult patients with multiple sclerosis.
- •Waist Circumference correlates with lower cognitive function and increased disability.
- •Neurofilament light chain higher levels in the cerebrospinal fluid relate with lower high-density lipoprotein cholesterol.
Abstract
Background
Metabolic syndrome and multiple sclerosis [MS] share the presence of chronic inflammation
in their pathogenic mechanisms. This study aimed to estimate the prevalence of metabolic
syndrome parameters in MS and their association with disease disability, cognitive
function, and Neurofilament Light chain [NfL] levels.
Methods
Clinical, analytical, and magnetic resonance imaging data were obtained through medical
records. Disease disability was measured by the Expanded Disability Status Scale [EDSS],
the MS Severity Scale [MSSS] along with cognitive impairment by the Brief International
Cognitive Assessment for MS [BICAMS] and Word List Generation test [WLG]. Metabolic
syndrome parameters were evaluated by fasting blood glucose, triglycerides, high-density
lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol, total cholesterol,
blood pressure, and waist circumference [WC]. We also analysed serum leptin and ghrelin
and cerebrospinal fluid NfL.
Results
Our sample included 51 people with MS, 34 (66.7%) females, mean age of 38.20±12.12
years and median disease duration of 3 years (P25=2.0, P75=5.0). Multivariate linear
regression analysis confirmed that WC correlates with EDSS (β=0.04, p=.001) and MSSS
(β=0.07, p=.002) as well as Brief Visuospatial Memory Test-Revised (β=-0.29, p=.008),
WLG (β=-0.20, p=.039). NfL is also negatively associated with HDL-C (β=-4.51, p=.038).
Conclusions
Waist circumference is associated with disability and deficits in cognitive tests.
A decrease in HDL-C is associated with an increase in NfL. This suggests metabolic
syndrome might be an important factor in MS disease course.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Multiple Sclerosis and Related DisordersAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study.PLoS One. 2013; 8: e71058
- Cognitive patterns and progression in multiple sclerosis: construction and validation of percentile curves.J. Neurol. Neurosurg. Psychiatry. 2005; 76: 744-749
- Cognitive impairment in multiple sclerosis: an exploratory analysis of environmental and lifestyle risk factors.PLoS One. 2019; 14e0222929
- Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients.J. Lipid. Res. 2015; 56: 2010-2018
- The evolution of neurofilament light chain in multiple sclerosis.Front. Neurosci. 2021; 15642384
- Measures of general and abdominal obesity and disability severity in a large population of people with multiple sclerosis.Mult. Scler. 2020; 26: 976-986
- Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis.J. Neurol. 2019; 266: 2157-2163
- Lipid profile: causal relationship on cognitive performance in multiple sclerosis?.Mol. Biol. Rep. 2020; 47: 9667-9676
- A comprehensive definition for metabolic syndrome.Dis. Models Mech. 2009; 2 (5–6): 231-237
- Neurofilament light levels are associated with long-term outcomes in multiple sclerosis.Mult. Scler. 2020; 26: 1691-1699
- Diabetes and anxiety adversely affect cognition in multiple sclerosis.Mult. Scler. Relat. Disord. 2019; 27: 164-170
- Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case-control studies.J. Neurol. Neurosurg. Psychiatry. 2019; 90: 1059-1067
- Cholesterol and neurodegeneration: longitudinal changes in serum cholesterol biomarkers are associated with new lesions and gray matter atrophy in multiple sclerosis over 5 years of follow-up.Eur. J. Neurol. 2020; 27 (e4): 188
- BRBN-T validation: adaptation of the selective reminding test and word list generation.Arq. Neuropsiquiatr. 2015; 73: 867-872
- The correlation between dyslipidemia and cognitive impairment in multiple sclerosis patients.Mult. Scler. Relat. Disord. 2019; 36101415
- The relationship between cognitive function and body mass index in multiple sclerosis patients.Mult. Scler. Relat. Disord. 2019; 32: 37-40
- Body composition and disability in people with multiple sclerosis: a dual-energy x-ray absorptiometry study.Mult. Scler. Relat. Disord. 2019; 29: 41-47
- Prevalence of overweight, obesity and metabolic syndrome components in multiple sclerosis patients with significant disability.Eur. J. Neurol. 2015; 22: 1275-1279
- Cerebrospinal fluid neurofilament light chain is associated with Kynurenine pathway metabolite changes in multiple sclerosis.Int. J. Mol. Sci. 2020; 212665
- Multiple sclerosis severity score: using disability and disease duration to rate disease severity.Neurology. 2005; 64: 1144-1151
- Obesity and multiple sclerosis-a multifaceted association.J. Clin. Med. 2021; 102689
- Validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) in the Portuguese population with multiple sclerosis.BMC Neurol. 2018; 18: 172
- Cognition in multiple sclerosis. State of the field and priorities for the future.Neurology. 2018; 90: 278-288
- An adverse lipid profile is associated with disability and progression in disability, in people with MS.Mult. Scler. 2014; 20: 1737-1744
- Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.Lancet Neurol. 2018; 17: 162-173
- Cerebrospinal fluid concentrations of ghrelin in patients with multiple sclerosis.Neuro. Endocrinol. Lett. 2013; 34: 14-17
- Neurofilament light chain levels in multiple sclerosis correlate with lesions containing foamy macrophages and with acute axonal damage.Neurol. Neuroimmunol. Neuroinflamm. 2022; 9: e1154
- Association between circulating leptin levels and multiple sclerosis: a systematic review and meta-analysis.Postgrad. Med. J. 2018; 94: 278-283
Article info
Publication history
Published online: October 27, 2022
Accepted:
October 21,
2022
Received in revised form:
May 31,
2022
Received:
May 4,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
